Impacts of Fruit on the Gut Health and Human Health

San Diego State University

Status: Completed

Conditions: Cardiometabolic Health; Cognition; Healthy Aging

Treatments: Other: Fruit (2 cup eq); Other: Fruit restriction (1/2 cup eq)

Study type: Interventional

Funder types: Other

Identifiers

NCT05063929

5A297A

Details and patient eligibility

About

The objectives of this study are to investigate the effect of fruit consumption on the gut microbiota and their collective fecal and plasma metabolomes, vascular and cardiometabolic functions, cognition, and motor control.

Full description

The Investigators findings will provide data critical to the understanding of the effects of fruit intake on the gut microbiome and the capacity of the microbiota to biotransform nutrients contained within fruits as well as the subsequent impact on circulating status of those metabolites. Concurrently, health outcomes that may be linked to these changes including cognition, motor control, vascular function and cardiometabolic health risk markers will be assessed in healthy adults.

Enrollment: 40 patients

Sex: All

Ages: 30 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy men and women 30 to 70 years old

Exclusion criteria

• History of:

  • stroke or myocardial infarction
  • gastrointestinal disorders
  • neurological disorders (epilepsy, multiple sclerosis, Parkinson's disease, stroke, etc)
  • known metabolic disorders (liver, renal or clinically diagnosed diabetes)
  • drug treatment for lipid reduction or hypertension,
  • psychiatric medication use

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

Fruits

Experimental group

Description:

Participants will receive 2 cup eq fruits per day

Treatment:

Other: Fruit (2 cup eq)

Fruit restriction

Other group

Description:

Participants will receive 1/2 cup eq fruits per day

Treatment:

Other: Fruit restriction (1/2 cup eq)