Impacts of Metabolic Variation on Neuroendocrine Control of Reproduction

Vaud University Hospital Center

Status: Completed

Conditions: Neuroendocrine Reproductive Status

Treatments: Dietary Supplement: effect of metabolic variations on LH pulsatility

Study type: Interventional

Funder types: Other

Identifiers

NCT01058681

Swiss national science fund

Grant number 320030-124886 (Other Grant/Funding Number)

Details and patient eligibility

About

This study will evaluate the potential effects of a changing metabolic environment on GnRH hypothalamic neurons, by performing studies of LH pulsatility (basal and during clamp studies) in different groups of male subjects fed isocaloric and hypercaloric diets. The participation of other gastro-intestinal tract hormones to these regulations will be systematically evaluated.

Enrollment: 9 patients

Sex: Male

Ages: 18 to 25 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• male
• age between 18 and 25 years old
• no known pathology
• normal physical exam
• BMI between 20 and 25 kg/m2

Exclusion criteria

• history of endocrine disease
• no known infertility (no conception after 12 months of regular unprotected intercourse)
• abnormal results on the initial blood tests (CBC, fasting glucose and insulin, HbA1C, TSH, free T4, LH, FSH, inhibin B and total testosterone)

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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9 participants in 3 patient groups

isocaloric

Other group

Description:

impacts of isocaloric nutrition on LH pulsatility in euglycemic and hyperinsulinemic clamps

Treatment:

Dietary Supplement: effect of metabolic variations on LH pulsatility

hypercaloric

Other group

Description:

impacts of hypercaloric nutrition on LH pulsatility in euglycemic and hyperinsulinemic clamps

Treatment:

Dietary Supplement: effect of metabolic variations on LH pulsatility

per os and IV glucose during the clamp

Other group

Description:

impacts of per os glucose on LH pulsatility in euglycemic and hyperinsulinemic clamps

Treatment:

Dietary Supplement: effect of metabolic variations on LH pulsatility