Impaired Insulin-like Growth Factor-1 (IGF-1) Generation Causes Protein Catabolism and Poor Growth in Children With Crohn Disease

Nationwide Children's Hospital

Status: Terminated

Conditions: Crohns Disease

Treatments: Other: Examinations

Study type: Observational

Funder types: Other

Identifiers

NCT00946361

IRB09-00036

Details and patient eligibility

About

The investigators will prospectively recruit 26 children with moderate - severe active Crohn disease (PCDAI >30). Results will be compared to 26 patients in sustained remission (PCDAI <10 and physician global assessment of remission over the previous 6 months) who are matched for age and gender. Subjects will be studied at baseline and six months. The primary study end-points will be leucine rate of appearance (a measure of protein breakdown) and IGF-1 levels.

This study will test the hypothesis that children with greater disease severity will have worse longitudinal growth and protein catabolism. The investigators will also explore the secondary hypothesis that children with Crohn disease have abnormal IGF-1 generation which is linked to underlying inflammation and disease severity.

Enrollment: 1 patient

Sex: All

Ages: 5 to 15 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosed with Crohn disease by endoscopy and histologic samples
• Chronological and/or bone age 6-15 years old
• Tanner 1 - 2
• Willing to participate in our longitudinal evaluation

Exclusion criteria

• Concomitant persistent chronic infectious disease
• Inflammatory bowel disease not diagnosed as Crohn disease
• Immunological disorder (excluding Crohn disease)
• Associated severe concomitant chronic illnesses (CF, liver failure)
• Pregnancy

Trial design

1 participants in 1 patient group

Diagnostic

Treatment:

Other: Examinations