Impairment of Central Coherence in Restrictive Anorexia Nervosa (CoCA)

Nantes University Hospital (NUH)

Status: Completed

Conditions: Anorexia Nervosa

Treatments: Behavioral: One interview of 90 minutes with a part of cognitive assessment and a part of self-assessment

Study type: Interventional

Funder types: Other

Identifiers

NCT02381639

RC14_0301

Details and patient eligibility

About

The current etiological pathological model of anorexia nervosa is poly-factorial involving individual genetic and psychological factors, in close interaction with environmental, family and socio-cultural factors.

Among these factors, this study focuses on the central coherence process (cognitive ability to integrate complex information into a comprehensive meaning), in the active phase of the disease. Therefore, patients followed in the addiction service of the Nantes University Hospital will perform neuropsychological tests assessing executive functions involved in the process of central coherence.

Impairment of central coherence process could act as a maintenance factor of the disease, particularly in connection with body dysmorphic disorder. The therapeutic perspectives acting on the central coherence process like cognitive remediation deserve to deepen knowledge on the cognitive profile of patients with anorexia nervosa.

Enrollment: 122 patients

Sex: Female

Ages: 15+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• For the patients :

  • Woman.
  • Aged of more than 15 years and 3 months.
  • Followed in the addiction service of the University Hospital of Nantes (consultations and / or hospitalizations) for Restrictive Anorexia Nervosa (according to the diagnostic criteria of DSM-IV-TR).
  • French language mastered.
  • Having signed the consent if major and if not the legal representatives have signed the consent (for minors).

• For the volunteers :

  • Women.
  • Aged of more than 15 years and 3 months.
  • French language mastered.
  • Having signed the consent if major and if not the legal representatives have signed the consent (for minors).

Exclusion criteria

• For the patients :

  • Man

  • Age under 15 years and 3 months old

  • Current Renutrition by nasogastric tube

  • Personal history of:

    • Head injury, neurodegenerative diseases, epilepsy unbalanced, unbalanced endocrine disorder, mental retardation
    • Support for current or past cognitive remediation

  • Opposition of the patient and / or his legal representatives if minor

  • Subject under legal guardianship

  • Current participation or in the past to pharmacological research protocol (time since the end of their participation in the protocol less than one year)

  • French language not mastered

• For the volunteers :

  • Man

  • Age under 15 years and 3 months old

  • Current Renutrition by nasogastric tube

  • Personal history of:

    • Eating disorders
    • Head injury, neurodegenerative diseases, epilepsy unbalanced, unbalanced endocrine disorder, mental retardation
    • Support for current or past cognitive remediation

  • Opposition of the volunteer and / or his legal representatives if minor

  • Subject under legal guardianship

  • Current participation or in the past to pharmacological research protocol (time since the end of their participation in the protocol less than one year)

  • French language not mastered

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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122 participants in 2 patient groups

Patients

Other group

Description:

patients followed in the addiction service of the University Hospital of Nantes (consultations and / or hospitalizations) for restrictive anorexia nervosa

Treatment:

Behavioral: One interview of 90 minutes with a part of cognitive assessment and a part of self-assessment

Healthy volunteers

Other group

Description:

control subjects matched for age and sex with the patients

Treatment:

Behavioral: One interview of 90 minutes with a part of cognitive assessment and a part of self-assessment