Implementation of a New Strategy to Identify HNPCC Patients

Radboud University Medical Center

Status: Unknown

Conditions: Hereditary Nonpolyposis Colorectal Cancer; Colorectal Neoplasms

Treatments: Behavioral: Reminders for professionals; Behavioral: Distribution of educational materials; Behavioral: Feedback for professionals; Behavioral: Education for professionals

Study type: Interventional

Funder types: Other

Identifiers

NCT00141466

MIPA-2005

ZonMw nr. 945-14-107

Details and patient eligibility

About

The purpose of this study is to compare two different strategies to implement a new method to identify patients with HNPCC, which appeared cost-effective and feasible. The effectiveness, costs and feasibility of both of the implementation strategies will be assessed.

Full description

The Radboud University Nijmegen Medical Centre developed a new method to identify patients with HNPCC. This method appeared cost-effective and feasible. Using this new method 70% of the HNPCC patients will be identified as compared to less than 30% when the current method is used. However, this new method does not implement itself; large gaps exists between best evidence and daily practice. This study will compare an intensive strategy, consisting of distribution of educational materials, education, feedback and reminders, with a minimal strategy, only consisting of distribution of a critical care pathway. The aim is to find the most cost-effective strategy to implement the new method to identify patients with HNPCC in the Netherlands.

Enrollment: 360 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Colorectal cancer before the age of 50 years
• Second colorectal cancer at any age
• Colorectal cancer and other HNPCC associated extracolonic cancer irrespective of age at diagnosis
• Adenoma with high grade dysplasia diagnosed before the age of 40 years