ClinicalTrials.Veeva

Menu

Implementation of Genomics in Substance Use Disorder Treatment

The Washington University logo

The Washington University

Status

Completed

Conditions

Tobacco Use Cessation
Tobacco Use Disorder
Smoking Cessation

Treatments

Behavioral: Genetically-Informed RiskProfile
Other: Brief Cessation Advice

Study type

Interventional

Funder types

Other
NIH

Identifiers

NCT04768114
201704049
K12DA041449 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

Cigarette smoking remains one of the leading causes of preventable death. Effective smoking cessation medications exist but use of these treatments is low, making it difficult for most to quit smoking. Behavioral interventions are needed to engage current smokers in the process of quitting smoking and promote the use of evidence-based cessation medications.

At the same time, genetics influences one's smoking behaviors (e.g., how much they smoke, difficulty quitting) and risk of smoking-related diseases, yet these personalized factors have not been included in existing behavioral interventions. Incorporating these individualized factors into smoking cessation interventions may make them more personally engaging and thus motivating for treatment.

This study will pilot test a risk communication tool that is personalized to one's genetics and will demonstrate the feasibility of a larger trial to test the effect of this personalized genetically-informed intervention on smoking cessation.

Enrollment

148 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • At least 18 years of age
  • Smoked combustible cigarettes in past 30 days
  • Computer access for remote-based study visits

Exclusion criteria

  • Younger than 18 years of age
  • No computer access

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

148 participants in 2 patient groups

Genetically-Informed RiskProfile
Experimental group
Treatment:
Behavioral: Genetically-Informed RiskProfile
Brief Cessation Advice
Active Comparator group
Treatment:
Other: Brief Cessation Advice

Trial documents
1

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2026 Veeva Systems