Implementation of New Multimodal MRI Sequences by Fingerprint to Improve Ischemic Stroke Examination. (INDEX)

Grenoble Alpes University Hospital Center (CHU)

Status: Not yet enrolling

Conditions: Stroke, Ischemic

Treatments: Device: Achieva 3.0T dStream Philips

Study type: Interventional

Funder types: Other

Identifiers

NCT07199920

38RC23.0410

Details and patient eligibility

About

Currently, standard brain MRI takes 20 to 25 minutes, but in the case of ischemic stroke, every minute counts to limit the extension of the necrotic core, with the possibility of recanalizing the occluded artery (intravenous thrombolysis and/or mechanical thrombectomy).

The recent concept of MRI "Fingerprint" (Magnetic Resonance Fingerprinting, MRF) allows the production of a rapid single sequence and the extraction of numerous parameters.

Demonstrating the feasibility and interpretability of multimodal MRI images acquired in MRF would make it possible to consider implementing and, ultimately, replacing conventional sequences, with the aim of shortening acute stroke management times, increasing the number of sequences acquired within a short timeframe (by increasing informativeness), and thus improving patients' short and long-term vital and functional prognosis.

Enrollment: 10 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 18 years
• Subacute ischemic stroke patients (< 15 days after onset)
• Middle cerebral artery or anterior cerebral artery territory stroke
• Modified Rankin Scale (mRS) = 0-4

Exclusion criteria

* MRI contraindications

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Sequential Assignment

Masking: None (Open label)

---

10 participants in 1 patient group

Experimental

Experimental group

Description:

Every patient will perform classic brain MRI with additional MRF sequences.

Treatment:

Device: Achieva 3.0T dStream Philips