Implication of Human Papillomavirus (HPV) in Lichen Physiopathology in Human (HPVLichen)

Pasteur Institute

Status: Completed

Conditions: Lichen Planus

Treatments: Procedure: Human biological samples

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT02761122

ID-RCB number : 2015-A01697-42 (Other Identifier)

2015-058

Details and patient eligibility

About

Lichen planus is a chronic cutaneous and mucosal disease characterized by the infiltration of cluster of differentiation (CD) CD8 T lymphocytes, localized under the basal membrane and associated with apoptosis of basal keratinocytes, suggesting a reactivity of T lymphocytes toward keratinocyte antigen(s), so far unidentified. In a recent study, the research team at Institut Pasteur has demonstrated in a peculiar clinical form of lichen planus (erosive lichen planus), that the immunogenic target of CD8 T lymphocytes could be the immunodominant peptide of Human Papilloma Virus (HPV) 16.

In line with this recent work which shows for the first time a link between HPV-16 and an autoimmune disease, erosive lichen planus, the aim of te study is to test the hypothesis that HPV could be also involved in the pathogenesis of other clinical forms of lichen, such as non erosive lichen planus or lichen sclerosus.

Full description

Lichen planus is a chronic cutaneous and mucosal disease characterized by the infiltration of cluster of differentiation (CD) CD8 T lymphocytes, localized under the basal membrane and associated with apoptosis of basal keratinocytes, suggesting a reactivity of T lymphocytes toward keratinocyte antigen(s), so far unidentified. In a recent study, the research team at Institut Pasteur has demonstrated in a peculiar clinical form of lichen planus (erosive lichen planus), that the immunogenic target of CD8 T lymphocytes could be the immunodominant peptide of Human Papilloma Virus (HPV) 16.

In line with this recent work which shows for the first time a link between HPV-16 and an autoimmune disease, erosive lichen planus, the aim of te study is to to test the hypothesis that HPV could be also involved in the pathogenesis of other clinical forms of lichen, such as non erosive lichen planus or lichen sclerosus.

Regarding erosive lichen planus, the aim is to test the cytotoxic function of the previously identified CD8 T lymphocytes specific for HPV16 E711-20.

Enrollment: 21 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• At least 18 year-old
• Clinically or histologically confirmed lichen : Non-erosive lichen planus, Erosive lichen planus, or Sclerosus lichen
• At diagnosis of desease before treatment, or during flares of the disease, with or without intake or topical application of immunosuppressants
• Affiliated or beneficiary of a social security system
• Informed and written consent

Exclusion criteria

• Under 18 year-old,
• Legal protection measures,
• Inability to consent
• Pregnant or breastfeeding women.

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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21 participants in 1 patient group

Patients with lichen

Experimental group

Description:

Patients with non-erosive lichen planus, erosive lichen planus or lichen sclerosus. Human biological samples : * Blood sample * Skin or mucosal brushing * Skin or mucosal biopsy

Treatment:

Procedure: Human biological samples