Implication of Left veNtricle Vortex Flow Guided aNticOagulation Therapy for preVenting Apical Thrombus Formation In Patients With Acute myOcardial infarctioN: Multicenter Prospective Randomized Clinical Trial; INNOVATION Study

Yonsei University

Status: Completed

Conditions: Apical Thrombus Formation; Acute Myocardial Infarction

Study type: Observational

Funder types: Other

Identifiers

NCT01869998

4-2012-0040

Details and patient eligibility

About

Implication of left veNtricle vortex flow guided aNticOagulation therapy for preVenting Apical Thrombus formation In patients with acute myOcardial infarctioN: Multicenter Prospective Randomized Clinical Trial; INNOVATION study

Enrollment: 111 patients

Sex: All

Ages: 30 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patient is ≥ 30 years old
2. Acute anterior wall myocardial infarction showing akinetic or dyskinetic apical wall motion abnormalities on an initial transthoracic echocardiogram
3. Left ventricular ejection fraction less than 40%

Exclusion criteria

1. Prior history of myocardial infarction
2. Chronic medication with Coumadin
3. Contraindication of contrast echocardiography
4. Significant atrial or ventricular arrhythmia
5. Valvular heart disease more than moderate degree
6. Decompensated heart failure
7. Very poor echo window, which cannot evaluate the presence of apical thrombus

Trial design

111 participants in 3 patient groups

Low risk group (A)

Description:

(A)Vortex depth≥0.45

High risk group 1 (B)

Description:

(B)Vortex depth\<0.45 with anticoagulation

High risk group 2 (C)

Description:

(C)Vortex depth \<0.45 without anticoagulation