Importance of Aldosterone in the Pathogenesis of Hypertensive Heart Disease

University of Erlangen-Nürnberg Medical School

Status and phase: Completed; Phase 3

Conditions: Primary Hypertension

Treatments: Drug: placebo; Drug: spironolactone

Study type: Interventional

Funder types: Other

Identifiers

NCT00865501

KFO-TP5-I

Details and patient eligibility

About

The Renin-Angiotensin-Aldosterone-system is important in the development of cardiovascular organ damage caused by arterial hypertension. This study aims at evaluating the importance of aldosterone with regard to hypertension induced damage to the heart. In order to do this the investigators will perform a comparative cross-sectional study in hypertensives and normotensives. In addition as interventional part the hypertensives will be treated with a mineralocorticoid-receptor blocker (spironolactone).

Enrollment: 50 patients

Sex: Male

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis hypertension (BP higher than 139/89)

Exclusion criteria

• Antihypertensive pretreatment
• Contraindications against spironolactone
• Being unable to understand or comply with study procedures

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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50 participants in 2 patient groups, including a placebo group

1

Experimental group

Description:

spironolactone

Treatment:

Drug: spironolactone

2

Placebo Comparator group

Description:

placebo

Treatment:

Drug: placebo