İmportance of Scattered White Spots Detected in the Duodenum and Their Relationship wıth Zonulin

Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital

Status: Completed

Conditions: Duodenal Diseases; White Spot Lesion

Treatments: Diagnostic Test: sws grade 1; Diagnostic Test: control; Diagnostic Test: sws grade 2

Study type: Interventional

Funder types: Other

Identifiers

NCT06200129

zonulinsws

Details and patient eligibility

About

With our study, we aimed to determine whether there is a correlation between zonulin, which plays a crucial role in intestinal barrier function and is implicated in the etiopathogenesis of many chronic and autoimmune diseases, and scattered white spots lesions associated with lymphatic stasis and inflammation in the duodenum.

Full description

During esophagogastroduodenoscopy (EGD), rarely encountered lesions in the duodenum present as scattered white spots (SWS) on the normal mucosa. Although not fully understood in terms of specific association with any particular disease and clinical significance, some studies have often observed chronic non-specific duodenitis (CND) and intestinal lymphangiectasia (IL) in lesions with SWS. This condition is thought to be related to lymphatic stasis.

Patients included 63 individuals with identified SWS during EGD and 30 patients with a normal appearance of the duodenal mucosa were selected as the control group. SWS lesions were categorized into two groups, grade 1 and grade 2, based on the degree of density and endoscopic appearance. Biopsies were taken from the duodenum, antrum, and corpus. It was examined for IL, CND, giardiasis, and villous atrophy. Venous blood samples were collected from all patients for serum zonulin levels.

Enrollment: 93 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with scattered white patchy lesions in the duodenum on endoscopy and control group patients with normal duodenum on endoscopy.

Exclusion criteria

• active gastroenteritis
• acute kidney failure
• chronic kidney failure
• type-1 diabetes
• inflammatory bowel disease
• duodenal ulcer,
• duodenal tumor
• autoimmune diseases

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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93 participants in 3 patient groups

sws grade 1

Experimental group

Description:

The group that defined as scattered white spots on the normal duodenal mucosa that could not be wiped away by washing, appearing as white spots

Treatment:

Diagnostic Test: sws grade 1

sws grade 2

Experimental group

Description:

The group that defined as a diffuse or patchy white appearance on villi that could not be wiped away by washing on the mucosa.

Treatment:

Diagnostic Test: sws grade 2

control

Experimental group

Description:

The group with a normal appearance of the duodenal mucosa, where scattered white spots were not detected.

Treatment:

Diagnostic Test: control