Improve Acute Reperfusion Treatment Quality for Stroke in China, IMPROVE: Stroke Care in China

Capital Medical University

Status: Completed

Conditions: Ischemic Stroke

Treatments: Behavioral: improvement of quality of stroke care

Study type: Interventional

Funder types: Other

Identifiers

NCT03578107

KY 2018-044-01

Details and patient eligibility

About

In order to bridge the great gaps, Chinese Stroke Association (CSA) and American Heart Association (AHA) sought to develop, conduct, and assess a multifaceted quality improvement intervention to increase the adherent rate of IV tPA and ET and improve 3-month clinical outcomes for these patients through our cluster-randomized stepped-wedge IMPROVE: Stroke in China trial.

Enrollment: 15,895 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Hospitals：

1. Voluntary.
2. Hospitals from CSCA.
3. Secondary or tertiary public hospitals with an emergency department and neurologic wards that receive patients with AIS.
4. Have a 24*7 on-call stroke team.
5. Have the capacity of IV rt-PA thrombolytic therapy or/and endovascular treatment.
6. Implement at least 10 patients' rt-PA or/and endovascular treatment during the last year.
7. Admit at least 5 patients of acute ischemic stroke within 24 hours after onset each month.
8. Have full desire to improve the procedure of treatment of acute ischemic stroke.
9. Have good cooperation among Neurology department, Emergency department, Interventional department, Neurosurgery department, Laboratory and Radiology department.

Patients： Patients who are ≥18 years old were eligible for inclusion if they presented with acute ischemic stroke diagnosed by CT and/or MRI and arrived at hospital within 6 hours after symptom onset.

Exclusion criteria

Hospitals：

1. Hospitals that can not comply with the protocol and finish the research.
2. Grade-one hospitals and non cerebral vascular disease specialized hospitals.
3. Hospitals involved in other stroke care quality improvement projects or relevant clinical trials.

Patients：

1）Patients refuse to participate in this study

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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15,895 participants in 3 patient groups

Improvement intervention1

Other group

Description:

receive the following improvement intervention for 18 months：

Treatment:

Behavioral: improvement of quality of stroke care

Improvement intervention2

Other group

Description:

receive the following improvement intervention for 12 months：

Treatment:

Behavioral: improvement of quality of stroke care

Improvement intervention3

Other group

Description:

receive the following improvement intervention for 6 months：

Treatment:

Behavioral: improvement of quality of stroke care