Improved Basophil Activation Test (BAT) in the Diagnostics of Drug Allergy

The Republican Research and Practical Center for Epidemiology and Microbiology

Status: Unknown

Conditions: NSAID-Induced Anaphylactoid Reaction; Drug Allergy; Antibiotic Allergy

Study type: Observational

Funder types: Other

Identifiers

NCT03164044

RRPCEM_BAT

Details and patient eligibility

About

Current study evaluates the use of the improved Basophil Activation Test (BAT) in the diagnostics of IgE-mediated allergy to antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs).

Full description

Current study evaluates the use of the improved Basophil Activation Test (BAT) in the diagnostics of IgE-mediated allergy to antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs). Among commonly used CD63/CD203c markers, newly proposed molecules, such as CD69, CD107a, CD164, CD13, CD11b and CD300a will be assayed. Results obtained together with the other clinical data will be used to calculate sensitivity and specificity of the method.

Enrollment: 45 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• suspected allergy to antibiotics or NSAIDs in the last 1 year.

Exclusion criteria

• autoimmune diseases;
• HIV;
• hepatitis B/C;
• other acute or chronic infectious diseases;
• malignant neoplasms;
• leukemia;
• other severe acute or chronic intercurrent diseases;
• pregnancy/lactation;
• refuse of patient to participate in the trial.

Trial design

45 participants in 1 patient group

Patients with drug allergy

Description:

Patients with drug allergy to antibiotics or NSAIDs