Improved Fertility After Exercise in Overweight/Obese Women (FertilEX)

N

Norwegian University of Science and Technology

Status

Terminated

Conditions

Obesity
Infertility, Female

Treatments

Behavioral: Exercise

Study type

Interventional

Funder types

Other

Identifiers

NCT01933633
FertilEX

Details and patient eligibility

About

Overweight/obesity is associated with sub-fertility. The investigators will assess if regular exercise training prior to assisted fertilization will improve pregnancy rate in overweight/obese women referred to assisted fertilization. It is expected that training will be successful in increasing pregnancy rate

Full description

Obesity is associated with several diseases, as type 2 diabetes, cardiovascular disease and some types of cancer, this is of great concern for the public health. Also, of more immediate importance for these women; obesity is associated with increased risks of sub-fertility. The overall aim of the current project is to expand the knowledge about effective interventions to prevent the increasing prevalence of obesity-associated sub-fertility in population. One cause of the increased referral rate for in-vitro fertilization is the growing prevalence of overweight and obesity. Currently, about 700 couples are annually referred for in-vitro fertilization at St.Olav's Hospital. In this interdisciplinary trial, involving physiotherapists, exercise physiologists, gynecologists, and basic researchers, the effects of regular high intensity exercise training on fertility in sub-fertile overweight and obese women will be investigated.

Enrollment

18 patients

Sex

Female

Ages

18 to 50 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • body mass index (weight in kg/height in cm squared) >25
  • accepted for assisted fertilization treatment at St.Olav's hospital

Exclusion criteria

  • low responders, defined as AMH <2 pmol/L or < 5 oocytes in prior in vitro fertilisation (IVF)/Intracytoplasmic sperm injection (ICSI) cycles or antral follicle count (AFC) < 5
  • current or previous Metformin use (a wash-out period of > four weeks)

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

18 participants in 2 patient groups

Exercise
Experimental group
Description:
Regular exercise training for 10 weeks prior to assisted fertilisation
Treatment:
Behavioral: Exercise
Control
No Intervention group
Description:
Standard care

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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