Improved Orthostatic Tolerance = Better Cognitive Function in Parkinson's Disease (PaKogOH)

RWTH Aachen University

Status: Completed

Conditions: Autonomic Failure; Cognitive Impairment; Hypotension, Orthostatic; Parkinson Disease

Treatments: Other: Physiotherapy

Study type: Interventional

Funder types: Other

Identifiers

NCT03900000

13-131

Details and patient eligibility

About

Study on orthostatic Hypotension in Parkinson's disease

Full description

Orthostatic hypotension (OH) in Parkinson's disease (PD) may not only be related to dizziness or light headedness but to deficits in attention, visual, and verbal memory. Would a successful treatment of OH which includes physiotherapy significantly improve OH and these cognitive deficits? By means of a randomized cross-over trial, we want to measure and compare the effects of OH therapy on orthostatic tolerance, as well as on attention, visuo-spatial working memory, and verbal memory in patients with PD. If confirmed, therapy of orthostatic hypotension would provide a sound and simple approach to improve those cognitive deficits originating from orthostatic hypotension.

Enrollment: 30 patients

Sex: All

Ages: 40 to 95 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Parkinson's patients
• Diagnostis of OH
• able to perform an ambulatory physiotherapy at Aachen University Hospital.

Exclusion criteria

• deep brain stimulation or Pacemaker
• severe psychiatric disease
• severe heart disease
• severe vascular encephalopathy
• dementia
• pregnant or lactating women
• extreme pain or immobility

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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30 participants in 2 patient groups

Short_Physiotherapy

Other group

Description:

one period of physiotherapy (8 weeks)

Treatment:

Other: Physiotherapy

Long_Physiotherapy

Other group

Description:

two periods of physiotherapy (à 8 weeks)

Treatment:

Other: Physiotherapy