Improvement in Baroreflex Sensitivity in OSAS

Tokai National Higher Education and Research System

Status: Unknown

Conditions: Obstructive Sleep Apnea Syndrome

Treatments: Device: continuous positive airway pressure therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT00284037

NU-06-A-0003

Details and patient eligibility

About

Individuals with obstructive sleep apnea syndrome (OSAS) are at high risk for cardiovascular morbidity and mortality. The effect of long-term nocturnal therapy with continuous positive airway pressure (CPAP) on daytime baroreflex sensitivity (BRS), a predictor of cardiac death, was investigated in OSAS patients.

Sex: All

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• obstructive sleep apnea syndrome

Exclusion criteria

• diabetes mellitus, chronic obstructive lung disease, coronary or valvular heart disease, congestive heart failure, renal failure, or endocrine dysfunction. Moreover, none of them were taking b-blockers, vasodilators, or inotropic agents at the time of enrollment in the study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)