Improvement in Glycemic Response After Bariatric Surgery

Weizmann Institute of Science

Status

Enrolling

Conditions

Bariatric Surgery

Treatments

Procedure: sleeve gastrectomy surgery

Procedure: gastric bypass surgery

Procedure: control

Study type

Observational

Funder types

Other

Identifiers

NCT05325736

0046-21-TLV

Details and patient eligibility

About

decipher the role of microbiota in glycemic response change after bariatric surgery

Full description

Despite the vast knowledge linking the gut microbiome to metabolism and the glucose response, the relation still remains unclear. hopefully, a deep understanding of the mechanisms underlying metabolic improvement following bariatric surgery will make it possible to identify targets for pharmacological intervention, which will reduce the need for surgery and its risks.

Previous studies have characterized the microbiome after bariatric surgery, but most suffer from methodological limitations.

The current study has the potential to be innovative and make a significant contribution to understanding the mechanisms involved in early metabolic improvement after bariatric surgery.

Enrollment

120 estimated patients

Sex

All

Ages

18 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

candidates of bariatric surgery or cholecystectomy
age 18-70
male/female

Exclusion criteria

previous bariatric surgery
type 1 diabetes
antibiotic treatment 3 months prior to the study
probiotic treatment 3 months prior to the study
chronic disease - gastrointestinal disease, malignancy, psychiatric disorder, endocrinologic disorders
any pathologic findings during endoscopy
participants who will suffer from a post-operation complication