Improvement in Glycemic Response After Bariatric Surgery

W

Weizmann Institute of Science

Status

Enrolling

Conditions

Bariatric Surgery

Treatments

Procedure: control
Procedure: gastric bypass surgery
Procedure: sleeve gastrectomy surgery

Study type

Observational

Funder types

Other

Identifiers

NCT05325736
0046-21-TLV

Details and patient eligibility

About

decipher the role of microbiota in glycemic response change after bariatric surgery

Full description

Despite the vast knowledge linking the gut microbiome to metabolism and the glucose response, the relation still remains unclear. hopefully, a deep understanding of the mechanisms underlying metabolic improvement following bariatric surgery will make it possible to identify targets for pharmacological intervention, which will reduce the need for surgery and its risks. Previous studies have characterized the microbiome after bariatric surgery, but most suffer from methodological limitations. The current study has the potential to be innovative and make a significant contribution to understanding the mechanisms involved in early metabolic improvement after bariatric surgery.

Enrollment

120 estimated patients

Sex

All

Ages

18 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • candidates of bariatric surgery or cholecystectomy
  • age 18-70
  • male/female

Exclusion criteria

  • previous bariatric surgery
  • type 1 diabetes
  • antibiotic treatment 3 months prior to the study
  • probiotic treatment 3 months prior to the study
  • chronic disease - gastrointestinal disease, malignancy, psychiatric disorder, endocrinologic disorders
  • any pathologic findings during endoscopy
  • participants who will suffer from a post-operation complication

Trial design

120 participants in 3 patient groups

sleeve gastrectomy surgery
Description:
participants undergoing sleeve gastrectomy surgery for weight reduction
Treatment:
Procedure: sleeve gastrectomy surgery
gastric bypass surgery
Description:
participants undergoing gastric bypass surgery for weight reduction
Treatment:
Procedure: gastric bypass surgery
cholecystectomy
Description:
participants undergoing cholecystectomy
Treatment:
Procedure: control

Trial contacts and locations

2

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Central trial contact

Avner Leshem, MD

Data sourced from clinicaltrials.gov

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