Improvement of Anorectal Function While Preserving of Inferior Mesenteric Artery Performing Left Hemicolectomy for Diverticulosis (IPIMAL)

University of Roma La Sapienza

Status and phase: Completed; Phase 3

Conditions: Defecatory Disorders After Left Colonic or Rectal Resection

Treatments: Procedure: Inferior Mesenteric Artery Ligation; Procedure: Inferior Mesenteric Artery Preservation

Study type: Interventional

Funder types: Other

Identifiers

NCT01326052

DS-004

Details and patient eligibility

About

The aim of the study is to evaluate the anorectal function after hemicolectomy if we preserve or not the Inferior Mesenteric Artery (IMA). This study wants to demonstrate that IMA preservation could improve patient's quality of life reducing incontinence and/or constipation rate.

Enrollment: 150 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age from 18 to 80 years
• BMI<35
• Presence of symptomatic diverticular disease
• ASA I-III

Exclusion criteria

• age > 80 years
• BMI>35
• ASA IV
• Hinchey III-IV
• Past performed procedure that could be modify the nervous pattern (i.e. colorectal surgery, left nephrectomy, hysteroannessectomy)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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150 participants in 2 patient groups

Inferior Mesenteric Artery Preservation

Experimental group

Description:

Performing left hemicolectomy the IMA was preserved ligating close to the colonic wall the sigmoids arteries.

Treatment:

Procedure: Inferior Mesenteric Artery Preservation

Inferior Mesenteric Artery Ligation

Active Comparator group

Description:

Performing left hemicolectomy the IMA is ligated and sectioned after the origin of left colic artery

Treatment:

Procedure: Inferior Mesenteric Artery Ligation