Improvement of Foodallergy Diagnostic in Gastrointestinal Tract

University of Erlangen-Nürnberg Medical School

Status: Completed

Conditions: Food Allergy

Treatments: Diagnostic Test: Cytobrush

Study type: Interventional

Funder types: Other

Identifiers

NCT03151252

Foodallergy in Colon

Details and patient eligibility

About

Currently, diagnostic possibilities for the detection of food allergy in the gastrointestinal tract are scarce. The endoscopic segmental Lavage is the method of choice, but it´s controversial.

Additional to the endoscopic segmental lavage fluid a cytobrush is used for collecting the mucosa cells and biopsies are taken. Comparative to the Lavage specific IgE antibodies, Tumor necrosis factor- alpha, Eosinophilic cation protein and mastcell tryptase were measured.

Enrollment: 60 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• all patients with suspicion of food intolerance and confirmed food allergy

Exclusion criteria

• pregnant and patients under allergy medication (antihistaminic, cortison)

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 3 patient groups

Food allergy

Other group

Description:

Patients with confirmed foodspecific- IgE antibodies in blood

Treatment:

Diagnostic Test: Cytobrush

healthy controls

Other group

Description:

participants without foodspecific- IgE antibodies in blood and other gastrointestinal symptoms

Treatment:

Diagnostic Test: Cytobrush

gastointestinal symptoms without foodallergy in blood

Other group

Description:

Patients without foodspecific- IgE antibodies in blood, but with gastrointestinal symptoms

Treatment:

Diagnostic Test: Cytobrush