Improvement of Liver Function in Liver Cirrhosis Patients After Autologous Mesenchymal Stem Cell Injection:a Phase I-II Clinical Trial

Shahid Beheshti University of Medical Sciences

Status and phase: Completed; Phase 2; Phase 1

Conditions: Cirrhosis; Liver Failure

Treatments: Procedure: injection of progenitor of hepatocyte drived from Mesenchymal stem cell

Study type: Interventional

Funder types: Other

Identifiers

NCT00420134

348

Details and patient eligibility

About

The methods for separation of mesenchymal stem cell were established in 2001. These cells can differentiate to osteocytes, hepatocytes, chondrocytes, myocytes and etc,. In this study the investigators try to separate mesenchymal stem cell from end stage liver disease, then these cells will be differentiated to progenitor of hepatocytes, finally , the investigators injected these cells into portal vein under ultrasound guide. The investigators determine the effects of injected cells in reestablishment of liver function.

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• MELD score of at least 10
• Patent portal vein on color Doppler examination of the liver
• Normal alpha-feto protein serum levels
• Age more than 18
• Filling inform consent by patients and first degree family members

Exclusion criteria

• Any evidence of hepatocellular carcinoma on liver ultrasound studies
• Patients want to exclude from study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Single Blind