Improvements by a Protein-Rich Plant-Based Diet and Resistance Exercise Program for Active Ageing (IMPACT)

Amsterdam University of Applied Sciences

Status: Enrolling

Conditions: Protein Intake

Treatments: Other: Dietary and exercise intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT06172725

NL84531.018.23

Details and patient eligibility

About

High-protein intake and physical activity are important approaches to preserve muscle mass. Consuming high levels of high-quality proteins to preserve muscle mass is challenging with a plant-based diet. The healthy, older participants will follow a twelve-week high-protein vegetarian diet or high-protein omnivorous diet both in combination with a resistance training program. The change in protein intake and muscle mass will be assessed.

Enrollment: 80 estimated patients

Sex: All

Ages: 55+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Aged 55 years or older
• BMI 18.5-30 kg/m2
• Living independently
• Ability and willingness to comply with the protocol
• Written an informed consent
• Consent of the study physician

Exclusion criteria

• Alcohol abuse (more than 14 glasses per week (women) or more than 21 glasses per week (men)) or drug abuse in the opinion of the study physician (CBS et al., 2017)
• Inability to understand the Dutch language
• Cognitive impairment (MMSE more than 25)
• Diagnosed chronic disease that may interfere with protocol (e.g., cardiovascular, gastrointestinal, neurological, known renal diseases (eGFR more than 60 mL/min (Levey & Coresh, 2012), and/or diabetes)
• Current enrolment in an exercise program or other intervention study
• Planned a holiday during the intervention period and is unable to attend training sessions for more than 1 week

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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80 participants in 2 patient groups

High-Protein Vegetarian Diet

Experimental group

Description:

High-protein vegetarian diet (no meat/fish)

Treatment:

Other: Dietary and exercise intervention

High-Protein Omnivorous Diet

Active Comparator group

Description:

High-protein omnivorous diet

Treatment:

Other: Dietary and exercise intervention