Improving a Bayesian Model's Survival Estimates in Patients Needing Surgery for Bone Metastases

Memorial Sloan Kettering Cancer Center (MSK)

Status: Active, not recruiting

Conditions: Bone Metastases

Treatments: Other: blood sampling, the SF-36 questionnaire

Study type: Observational

Funder types: Other

Identifiers

NCT01470105

11-121

Details and patient eligibility

About

The goal of this study is to improve how we estimate survival of people with cancer that has spread to their bone. There have been previous attempts to estimate survival of people with cancer that spread to the bone, but they have not been accurate. This study will try to improve the way we estimate survival in people with cancer that has spread to their bone by looking to see if a physician assessment and a patient assessment of the health status can be blended to give a better estimate of survival than patients or doctors alone.

Enrollment: 230 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ≥ to 18 years of age
• Diagnosed with a metastatic malignancy
• histologically proven in oligometastatic disease or by clinical suspicion in widely metastatic disease
• by conventional radiographs, cross sectional imaging and/or scintigraphy
• Scheduled for an orthopaedic operative intervention for skeletal metastases at MSKCC or Montefiore Medical Center including, not limited to the following:
• Resection
• Intramedullary Fixation
• Prophylactic fixation
• Curettage and cementation
• Internal fixation
• Arthroplasty
• Spine stabilization

Exclusion criteria

• None

Trial design

230 participants in 1 patient group

pts bone metastases

Description:

This is a prospective, cross sectional, human use study conducted using patients with bone metastases requiring orthopaedic stabilization. Though this is an observational study, blood sampling, the SF-36 questionnaire, and ECOG performance status, and correlative studies will be performed.

Treatment:

Other: blood sampling, the SF-36 questionnaire