Improving Bone Health in Adolescent Girls: The Youth Osteoporosis and Understanding Total Health (YOUTH) Study

United States Department of Health and Human Services (HHS)

Status and phase

Completed

Phase 1

Conditions

Osteoporosis

Treatments

Behavioral: Increased high impact activity and resistance training

Behavioral: Diet with increased fruits, vegetables, and calcium

Study type

Interventional

Funder types

NIH

Identifiers

NCT00067600

R01HD037744

Details and patient eligibility

About

Osteoporosis affects nearly half of all American women over age 50. During the teenage years, girls can increase bone growth to decrease their risk of osteoporosis later in life. This study will test whether girls can change their food intake and physical activity patterns in ways that will increase their bone growth during the mid-teen years.

Full description

Osteoporosis-related fractures incur an annual cost in the United States of more than $8 billion. Peak bone mass is achieved in the late teens and early 20s. An important component of a lifelong osteoporosis prevention strategy is to maximize bone mineral content during the teen years and establish lifestyle patterns that will help maintain bone mineral content through menopause. This trial will test the efficacy of a comprehensive lifestyle intervention to build bone and prevent bone loss among adolescent women 14 to 16 years of age.

Participants in this study will be randomized to either an intervention group or an attention control group. The intervention program includes a physical activity component involving high impact and spinal motion activities and a diet component rich in fruits, vegetables, and calcium. Participants will take part in group and individual meetings and activities and receive coaching telephone calls. Participants will be assessed at study entry and two annual follow-up visits. Primary outcome measures include objective measures (serum folate and carotenoids urinary sodium, lean body mass, accelerometer measure of physical activity) and self-reports.

Sex

Female

Ages

14 to 16 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

High school freshman or sophomore
Body mass index (BMI) from 16 through 23
Member of Kaiser Permanente Northwest Health Plan
Parent or guardian willing to participate

Exclusion Criteria

Co-morbidity requiring a specific diet
Medication which contraindicates consuming a high-fiber diet
Life-threatening disease or other condition that would interfere with study participation
Current or past medically or self-diagnosed eating disorder
Current behaviors consistent with eating-related disorder
Pregnancy
Diagnosis of psychological disorder or difficulty within the past year