Improving Glycogen Liver Content Will Improve Post-operative Liver Function in Patients Undergoing Major Liver Resections

McGill University

Status: Completed

Conditions: Liver Function

Treatments: Dietary Supplement: high calorie diet 35 kcal/kg; Drug: Intravenous normal saline (NS 0.9); Drug: hyperinsulinemic normoglycemic clamp; Drug: dextrose 10% (D10W ®) infusion

Study type: Interventional

Funder types: Other

Identifiers

NCT00774098

SDR-06-012

Details and patient eligibility

About

We would like to study the effect of preserving liver glycogen storage by using intravenous dextrose infusion on postoperative liver function and complications after major liver resections.

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18 years or older
• planned to undergo a major liver resection at McGill University Health Center (MUHC)

Exclusion criteria

• patients known with chronic viral liver disease
• uncontrolled or type one diabetes mellitus (DM)
• patients on oral beta-blocker agents
• patients with unresectable disease determined intra-operatively
• patients unable to give consent for the study.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups, including a placebo group

Control Group

Placebo Comparator group

Description:

Intravenous normal saline (NS 0.9) started just before induction, and titrated to hemodynamic parameters and urine output

Treatment:

Drug: Intravenous normal saline (NS 0.9)

GICP

Experimental group

Treatment:

Drug: hyperinsulinemic normoglycemic clamp

Drug: dextrose 10% (D10W ®) infusion

Dietary Supplement: high calorie diet 35 kcal/kg