Improving Healing in Children After Tooth Extraction Using Laser Therapy or Hyaluronic Acid (LLLT vs HA)

Cairo University (CU)

Status: Not yet enrolling

Conditions: Low Level Laser Therapy; Extraction Socket Healing; Mesh; Tooth Extraction Site Healing; Badly Decayed Molars; Hyaluronic Acid Gel for Preservation the Extraction Socket; Healthy Volunteer

Treatments: Device: Low-Level Laser Therapy; Drug: Hyaluronic Acid (HA)

Study type: Interventional

Funder types: Other

Identifiers

NCT07205640

LLLTvsHA-2025

Details and patient eligibility

About

Tooth extraction may be an unpleasant and painful experience for children, Post-extraction wound healing. Low-level laser therapy (LLLT) is a widely used adjuvant treatment for wound healing, resulting in both an increase in cell number and an increase in cell metabolism. HA it is an important component of the extracellular matrix and a constituent of the neural, connective, and epithelial tissues.

Full description

Tooth extraction may be an unpleasant and painful experience for children. Pain felt during dental treatment, especially tooth extraction, is the most common complication. Pain management during and after tooth extraction is part of behavioral guidance, especially in pediatric patients.

Post-extraction wound healing and pain perception are related to hostrelated factors such as the patient's immune system, the use of painkillers and antibiotics, the presence of infection in the region, and the atraumatic nature of the procedure. Low-level laser therapy (LLLT) is a widely used adjuvant treatment for wound healing. It is based on the idea that exposure to a specific wavelength can alter cellular behavior, resulting in both an increase in cell number and an increase in cell metabolism. Aside from not having any negative effects, LLLT is an a thermic, photobiological, and nondestructive therapy approach.

HA it is an important component of the extracellular matrix and a constituent of the neural, connective, and epithelial tissues. Among the many biological effects of HA are its functions in cell differentiation, wound healing, inflammation, embryological development, and viscoelasticity.

Enrollment: 36 estimated patients

Sex: All

Ages: 6 to 10 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Children aged from six to ten years.
2. Children of both genders.
3. Children with badly decayed first permanent molar beyond repair and indicated for extraction.
4. Parents acceptance to participate in the study.

Exclusion criteria

1. Medically compromised children.
2. Uncooperative children.
3. Children who will not attend the follow up visits

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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36 participants in 2 patient groups

Low-Level Laser Therapy (LLLT)

Experimental group

Description:

Participants in this arm will receive low-level laser therapy (LLLT) immediately after extraction of the first permanent molar.

Treatment:

Device: Low-Level Laser Therapy

Hyaluronic Acid (HA)

Experimental group

Description:

Participants in this arm will receive hyaluronic acid (HA) immediately after extraction of the first permanent molar.

Treatment:

Drug: Hyaluronic Acid (HA)