Improving Metabolism With HDL Cholesterol

Bayside Health

Status: Completed

Conditions: Diabetes; Heart Disease

Treatments: Drug: rHDL

Study type: Interventional

Funder types: Other

Identifiers

NCT00395148

175/04

Details and patient eligibility

About

High levels of good cholesterol (HDL) in our blood decreases our chance of having a heart attack. This relates in part to the role good cholesterol plays in reducing build up of fat in the arteries. However, good cholesterol has many other protective effects. We have recently identified three enzymes (proteins) activated by HDL in cells lining the blood vessels, which may be responsible for some of HDL's protective actions.

Enrollment: 13 patients

Sex: Male

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged 18 - 65 years
• Free of overt coronary disease
• Body mass index <35 kg.m-2
• Fasting plasma glucose > 7 mmol/L-1
• No major illness

Exclusion criteria

• Unable to give informed consent
• Smokers
• Abnormal LFT, U&E, FBE or creatinine

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind