Improving Mobility in Diabetic Patients Through Resistance Training

Maastricht University Medical Centre (MUMC)

Status: Completed

Conditions: Diabetic Patients With Polyneuropathy

Treatments: Other: resistance training

Study type: Interventional

Funder types: Other

Identifiers

NCT00759265

06-3-031

Details and patient eligibility

About

Impaired mobility is a major health problem affecting many subjects with diabetes mellitus. It is associated with loss of quality of life and it is a strong predictor for poor health outcomes. Reduced lower extremity muscle function, as a consequence of diabetic polyneuropathy, is a major cause of impaired mobility. We hypothesize that a programme of resistance training will counterbalance the effects of polyneuropathy on muscle wasting, and will improve mobility and associated quality of life.

The objective of this study is to develop a resistance training intervention that improves mobility and quality of life in diabetic patients. It is also our intension to achieve a better understanding of the relation between diabetic neuropathy and muscle weakness, limited mobility and quality of life. Moreover, insight will be gained in optimizing training programmes for neuropathic patients.

Enrollment: 160 patients

Sex: All

Ages: 50 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• diabetic patients with polyneuropathy:
• valkscore >5;
• diabetic type 2;
• age >50 years

Exclusion criteria

• muscular related diseases;
• ischemia;
• amputation (except for toe amputation)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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160 participants in 2 patient groups

resistance training

Experimental group

Description:

During 24 weeks, the patients of the intervention group will participate in a resistance training program. Two subsequent intervention programmes will be offered. Initially the first 12 week resistance trainings stage will aimed at improving function of lower leg muscles; subsequently a more extended programme affecting total limb musculature (lower- and upper leg) will be provided (also 12 weeks). During these trainings period, patients will train 3 times a week; once a plenary training session of 1,5 hour provided by a physical therapist. And 2 trainings sessions of half an hour each, by them selves at home.

Treatment:

Other: resistance training

control

No Intervention group

Description:

No intervention was prescribed