Improving Negative Symptoms of Psychosis In Real-world Environments (INSPIRE)

University of California San Diego

Status

Completed

Conditions

Schizophrenia

Treatments

Behavioral: Goal focused supportive contact

Behavioral: CBSST-CCT

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT02170051

130424

1R34MH101250 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

This study will compare Cognitive Behavioral Social Skills Training-Compensatory Cognitive Training (CBSST-CCT) to a goal-focused supportive contact group to see which intervention better improves symptoms and functioning in people with schizophrenia.

Enrollment

64 patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

MUST BE A RESIDENT OF BROADWAY HOME, SAN DIEGO, OR A SERVICE USER OF THE MEETING PLACE, ARETA CROWELL, OR PROJECT ENABLE.

Voluntary informed consent to participate
Age 18 to 65
DSM-IV diagnosis of schizophrenia or schizoaffective disorder based on MINI/SCID
Moderate-to-severe negative symptoms on the Clinical Assessment Interview for Negative Symptoms (CAINS total score >19)
≥ 6th grade reading level on the Wide Range Achievement Test-4 Reading subtest (needed for reading treatment manual)
Stable on medications; no changes within 3 months prior to enrollment

Exclusion criteria

Prior CBT, SST, or CCT in the past 5 years
Severe positive symptoms on the Positive and Negative Syndrome Scale (PANSS Delusions, Disorganization, Hallucinations, or Suspiciousness >5)
Severe depression on the Calgary Depression Scale for Schizophrenia (CDSS >8)
Ocular damage/disease/surgery/medications that affect pupil dilation
DSM-IV alcohol or substance dependence diagnosis in past 6 months based on the MINI or SCID
Level of care required interferes with outpatient therapy (e.g., hospitalized; severe medical illness) .