Improving Outcome in Schizophrenia Through Identification of Genetic Risk Factors

Northwestern University

Status: Completed

Conditions: Major Depression; Schizophrenia; Bipolar Disorder; Schizoaffective Disorder

Treatments: Procedure: genetic assay; Procedure: genetic analysis

Study type: Interventional

Funder types: Other

Identifiers

NCT00178932

9132

Details and patient eligibility

About

The goals of this study are to replicate previous findings of genetic predictors of response to clozapine and other antipsychotic drugs.

Enrollment: 37 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Patients with the diagnoses of schizophrenia or schizoaffective disorder, and bipolar disorder or major depression with psychotic features, or volunteers with no history of a psychotic disorder.

Exclusion criteria

Patients with DSM-IV diagnoses other than schizophrenia or schizoaffective disorder, and bipolar disorder or major depression with psychotic features.

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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37 participants in 2 patient groups

1 Outcome in schizophrenia with certain antipsychotic

Active Comparator group

Description:

clozapine

Treatment:

Procedure: genetic assay

Procedure: genetic analysis

2 Outcome in schizophrenia with other Antipsychotics

Active Comparator group

Description:

Other Antipsychotics

Treatment:

Procedure: genetic assay

Procedure: genetic analysis