Improving Safety and Accuracy of Stereotactic Brain Biopsies in Primary Central Nervous System Lymphoma.

San Donato Group (GSD)

Status: Enrolling

Conditions: Cerebral Lymphoma

Treatments: Diagnostic Test: MRI imaging; Diagnostic Test: Cerebral biopsy

Study type: Observational

Funder types: Other

Identifiers

NCT06263361

NCH02-2021

Details and patient eligibility

About

Primary central nervous system lymphoma (PCNSL) is an aggressive extranodal non- Hodgkin lymphoma exclusively localized into the nervous system. The aim of this study is to evaluate the MRI imaging characteristics of the peritumoral area (PTA) and to correlate this information to pathological findings.

Full description

Primary central nervous system lymphoma (PCNSL) is an aggressive extranodal non- Hodgkin lymphoma exclusively localized into the nervous system. It is a relatively rare disorder, accounting for only 3% of all primary brain tumors but due to its anatomical localization represents an important clinical and diagnostic challenge in onco-hematology. different MRI patterns of the peritumoral area (PTA) might correlate with different histopathological sensitivity regarding diagnostic potential out of contrast-enhanced region (CER). Improvements in the understanding of PTA diagnostic potentials is of great help in diagnosing patients with deep-seated lesions, who would otherwise be not eligible for stereotactic biopsy and therefore for a consequent adequate treatment.

Enrollment: 15 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients, undergoing stereotactic biopsy for newly diagnosed PSNCLs

Exclusion criteria

• Severe hepatic dysfunction
• Severe renal dysfunction
• Severe heart failure
• myocardial infarction and stroke within 90 days
• Hyperreactivity against contrast agents
• Pregnancy

Trial design

15 participants in 1 patient group

Included patients

Description:

Adult patients (\>18 years) candidates to stereotactic biopsy for histopathological diagnosis of intra-axial lesions suspected for primary central nervous system lymphoma (PCNSLs).

Treatment:

Diagnostic Test: Cerebral biopsy

Diagnostic Test: MRI imaging