Improving Safety of Antivenom in People Bitten by Snakes

University of Kelaniya

Status and phase

Completed

Phase 4

Conditions

Snake Bites

Treatments

Drug: adrenaline, promethazine, hydrocortisone

Study type

Interventional

Funder types

Other

Identifiers

NCT00270777

178A07

Details and patient eligibility

About

A study to increase the safety of polyvalent antivenom involving 1000 patients in three centres: low dose adrenaline, promethazine, & hydrocortisone (alone and in combination) to prevent acute adverse reactions to antivenom in people bitten by snakes: randomised, double blind, placebo-controlled trial.

Enrollment

1,000 estimated patients

Sex

All

Ages

12+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Above 12 years of age
Patients admitted to hospital after snake bite in whom antivenom is indicated
Patients who give informed consent

Exclusion criteria

Patients who are pregnant or nursing
Patients who are currently taking beta- or alpha-adrenoceptor antagonists, or tricyclic antidepressants
Patients in whom adrenaline may be contraindicated (this may include patients with the following: history of ischaemic heart disease, stroke, uncontrolled hypertension, and tachyarrhythmias)