Improving the Pregnancy Rate With Endometrial Sampling Before Intrauterine Insemination

McGill University

Status: Terminated

Conditions: Infertility; Clinical Pregnancy Rate

Treatments: Procedure: Endometrial sampling

Study type: Interventional

Funder types: Other

Identifiers

NCT00737984

SDR-08-004

Details and patient eligibility

About

Endometrial sampling improves the pregnancy rates in superovulation-IUI cycles

Full description

Endometrial sampling is performed using the standard technique in the outpatient department. Similarly, superovulation with gonadotrophins will be performed according to our standard practice.Endometrial sampling will be done in the follicular phase not later than day 10 of the cycle. Endometrial sampling will be performed using Pipelle sampling catheter. The Pipelle is inserted gently through the cervical canal into the uterine cavity and advanced slowly till just resistance felt by the operator. Then, the piston is withdrawn to create negative suction and gentle movement of Pipelle up and down in the uterine cavity is performed while it is against the uterine wall. The Pipelle catheter is withdrawn gently and any obtained specimen will be sent for histopathological examination.

Enrollment: 9 patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

1. All women undergoing superovulation with gonadotrophins and intrauterine insemination.
2. All women with cervical factor, mild male factor and/or unexplained infertility.
3. At least one patent Fallopian tube.

Exclusion criteria

1. Bilateral tubal disease
2. Severe male factor infertility
3. Intrauterine pathology (submucosal fibroid, endometrial polyp, adhesions)
4. Women with positive cervical culture and/or acute vaginal infection

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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9 participants in 2 patient groups

1

No Intervention group

Description:

Group 1 patients will receive standard superovulation-IUI treatment without endometrial sampling

2

Active Comparator group

Description:

Group 2 patients will receive standard superovulation-IUI treatment with endometrial sampling performed in the preceding cycle. It will be done in the follicular phase not later than day 10 of the cycle

Treatment:

Procedure: Endometrial sampling