Improvised Explosive Device (IED) Level Blasting of Human Blood With Slosh Prevention

Cincinnati Children's Hospital Medical Center

Status: Completed

Conditions: Brain Injuries

Treatments: Other: blood draw

Study type: Interventional

Funder types: Other

Identifiers

NCT03018548

2014-1087

Details and patient eligibility

About

To monitor changes in indicators of red cell damage such as extracellular hemoglobin, potassium (K-ABL), and lactate dehydrogenase (LD) post blast exposure.

Full description

Traumatic brain injury (TBI) causes significant morbidity and mortality, accompanied by high related costs. Recent hypotheses concerning the pathophysiology of TBI invoke Strain Shear Theory and Cavitation Theory. The invbestigators propose to test the importance of the latter by directing blast waves into containers that are either partially or completely filled with blood and measuring markers of lysis.

These experiments are designed to better understand the demonstrated effectiveness of mild jugular compression according to the principle of the Queckenstedt Maneuver to reduce the likelihood of TBI by filling up the compliance of the cranial space. A device (C-Collar) is being developed by Q30 Labs, LLC (Q30), to accomplish this effect.

Enrollment: 40 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• • Normal healthy volunteer

  • Able to provide written consent
  • Must be 18 years or older

Exclusion criteria

• • Unable to provide written consent

  • Recent penetrating brain trauma (within 6 months)
  • Under the age of 18 years

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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40 participants in 1 patient group

subject blood drawns

Experimental group

Description:

subjects will have blood drawn which will then be exposed to blast via CO2 cartridge

Treatment:

Other: blood draw