Impulse Oscillometry for Prognostication in Idiopathic Pulmonary Fibrosis (OSCILLO)

Regional University Hospital Center (CHRU)

Status: Completed

Conditions: Idiopathic Pulmonary Fibrosis

Treatments: Diagnostic Test: Impulse Oscillometry

Study type: Observational

Funder types: Other

Identifiers

NCT03898284

2018-A02300-55 (Other Identifier)

RIPH3-RNI18/OSCILLO

Details and patient eligibility

About

A 5-point decline of forced vital capacity expressed as % predicted, over 6 months, is the current definition of disease progression (fast decline in lung function) in idiopathic pulmonary fibrosis. There is a need for techniques allowing to characterize disease progression earlier, so that treatment may be adapted as early as possible in the lack of a response.

Hypothesis. Our hypothesis is that 3-month changes of lung function parameters measured by a novel technique, impulse oscillometry, predicts 6-month changes in forced vital capacity in idiopathic pulmonary fibrosis.

Full description

A 5-point decline of forced vital capacity expressed as % predicted, over 6 months, is the current definition of disease progression (fast decline in lung function) in idiopathic pulmonary fibrosis. There is a need for techniques allowing to characterize disease progression earlier, so that treatment may be adapted as early as possible in the lack of a response.

Hypothesis. Our hypothesis is that 3-month changes of lung function parameters measured by a novel technique, impulse oscillometry, predicts 6-month changes in forced vital capacity in idiopathic pulmonary fibrosis.

Enrollment: 54 patients

Sex: All

Ages: 45+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 45 years.
• Idiopathic Pulmonary Fibrosis defined Interstitial Lung Diseases with 1) lack of any known cause for Interstitial Lung Diseases and 2) either the "definite usual interstitial pneumonia" pattern at CT scan, or the usual interstitial pneumonia (definite, probable or possible) pattern at lung biopsy, according to the Lung Function Group of the French Pulmonology Society criteria.

Exclusion criteria

• History of chronic obstructive airway disease.
• History of congestive heart failure.
• Emphysema-fibrosis syndrome, defined as emphysematous lesions involving >15% of the lung area at the level of the aortic arch (upper lobes).
• History of lower respiratory infection or acute respiratory failure of any cause less than 90 days before inclusion.
• Opposition to data processing.

Trial design

54 participants in 1 patient group

Impulse Oscillometry

Description:

Patients with Idiopathic Pulmonary Fibrosis. The objective is to determine whether another lung function technique, impulse oscillometry, is of interest to identify disease progression before changes in forced vital capacity can be ascertained.

Treatment:

Diagnostic Test: Impulse Oscillometry