In-depth Immunological Investigation of COVID-19. (COntAGIouS)

Universitaire Ziekenhuizen KU Leuven

Status: Enrolling

Conditions: Coronavirus Infections

Treatments: Other: Patient sampling

Study type: Observational

Funder types: Other

Identifiers

NCT04327570

COntAGIouS

Details and patient eligibility

About

The COntAGIouS trial (COvid-19 Advanced Genetic and Immunologic Sampling; an in-depth characterization of the dynamic host immune response to coronavirus SARS-CoV-2) proposes a transdisciplinary approach to identify host factors resulting in hyper-susceptibility to SARS-CoV-2 infection, which is urgently needed for directed medical interventions.

Full description

The overall aim of this prospective study is to provide an in-depth characterization of clinical and immunological features of patients hospitalized in UZ Leuven because of SARS-CoV-2 infection. For this purpose, clinical data and blood, nasopharyngeal/rectal swab, and if safe, bronchoalveolar lavage (BAL) fluid and lung tissue samples will be collected from PCR- or CT-confirmed COVID-19 patients, with varying degrees of disease severity. Assessed characteristics will be compared between severe and non-severe COVID-19 patients, and between COVID-19 positive and negative ('control') patients.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients >/= 18 years old AND
• Hospitalised with PCR-confirmed and/or CT-confirmed SARS-CoV-2 disease

Exclusion criteria

• Age < 18 years old
• No informed consent

Trial design

100 participants in 2 patient groups

ICU-hospitalised COVID-19 patients

Description:

COVID-19 positive patients hospitalised in intensive care ('severe disease').

Treatment:

Other: Patient sampling

ward-hospitalised COVID-19 patients

Description:

COVID-19 positive patients requiring hospitalisation,not on intensive care department ('non-severe').

Treatment:

Other: Patient sampling