In-situ Cytokines Expression in the CNS in Amyotrophic Lateral Sclerosis (ALS)

CHU Brugmann University Hospital

Status: Completed

Conditions: Amyotrophic Lateral Sclerosis

Treatments: Other: in-situ cytokine expression

Study type: Observational

Funder types: Other

Identifiers

NCT02582385

CHUB-ALS

Details and patient eligibility

About

The investigators aim at exploring the differential/topographical in-situ expression of cytokines in the central nervous system (CNS) of patients who died with amyotrophic lateral sclerosis (ALS), using archived histopathology slides and residual paraffin blocks from autopsied cases. Previous studies from the investigators and other groups showed that inflammatory cytokines are implicated in several neurological affections, particularly neurodegenerative conditions. However, in-situ cytokine expression has never been studied so far in ALS. The investigators wanted to see if these neuro-mediators are involved in the neuromolecular chain/cascade underlying ALS.

Enrollment: 5 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients who died with amyotrophic lateral sclerosis, having been autopsied.

Exclusion criteria

• N/A

Trial design

5 participants in 2 patient groups

Amyotrophic lateral sclerosis (ALS)

Description:

Archived/residual histopathology sections and paraffin blocks, retrieved entirely from residual autopsy material from patients who died with an amyotrophic lateral sclerosis.

Treatment:

Other: in-situ cytokine expression

Control

Description:

Archived/residual histopathology sections and paraffin blocks, retrieved entirely from residual autopsy material from one non-ALS case.

Treatment:

Other: in-situ cytokine expression