In Vitro Follicle Activation in Patient With Premature Ovarian Failure Under 36 Years Old

Hacettepe University

Status

Completed

Conditions

Activation of Primordial Follicles

Treatments

Procedure: In vitro activation of primordial follicles by PTEN inhibitor and AKT stimulator

Study type

Interventional

Funder types

Other

Identifiers

NCT04131244

HU0616

Details and patient eligibility

About

This is a clinical trial that the investigators aim to validate In-vitro Activation (IVA) treatment protocol, which was previously defined by Kazuhiro Kawamura (MD) and Aaron Hsueh (PhD), in Turkish patient with Premature Ovarian Insufficiency (POI) under age 36.

Full description

The objectives of the study is as following;

Validation of the previously defined In-Vitro Activation Protocol approach in Turkish patients under 36 years old with Premature Ovarian Insufficiency (POI).
Giving an opportunity to young POI patient in Turkey for having genetically own baby.
Primary outcome measure would be live birth.
For activation of primordial follicles, phosphatase and tensin homolog (PTEN) inhibitor and protein kinase B (AKT) stimulator will be used.

Enrollment

10 patients

Sex

Female

Ages

18 to 36 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patient with POI
Short amenorrhea period (1 - 2 years)

Exclusion criteria

Having been treated with chemotherapy and/or radiotherapy;
Having been diagnosed with advanced stage of endometriosis (endometriomas)
Having been diagnosed with the chronic diseases such as diabetes, cardiac failure, kidney insufficiency, morbid obesity etc..
Presence of chromosomal abnormality (Turner, Fragile-X etc.)
Previous multiple laparotomies
Menopause >10 years
Accompanied azoospermia