In Vitro Maturation (IVM) of Human Oocytes

Weill Cornell Medicine (WCM)

Status: Terminated

Conditions: Infertility

Treatments: Procedure: Polar Body Biopsy with preimplantation genetic screening; Procedure: in vitro maturation

Study type: Interventional

Funder types: Other

Identifiers

NCT01550861

1201012117

Details and patient eligibility

About

The objectives of this study are to evaluate the clinical efficacy of Natural in vitro Fertilization and in vitro maturation.

Full description

Collection of one mature egg from a follicle in the ovary without gonadotropin medications (natural cycle IVF) results in low pregnancy rates. One way to improve natural cycle IVF is to combine this procedure with the removal of immature eggs from the ovary and mature these eggs in the laboratory ( in vitro maturation-IVM). The in vitro mature eggs are fertilized and the resultant embryos are cultured using conventional IVF techniques.

Enrollment: 2 patients

Sex: Female

Ages: 25 to 42 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Each subject must be female.
2. Each subject must have an indication for COH and IVF with or without ICSI.
3. Each subject must be willing and able to provide written informed consent for the trial
4. Each subject must be 25 to ≤42 years of age at the time of signing informed consent.
5. Each subject must have a normal cervical smear result (no atypical or abnormal cells, or in case of atypical squamous or glandular cells, no signs of malignancy; corresponding to Papanicolaou [PAP] I or II) obtained within 12 months prior to signing informed consent must be available

Exclusion criteria

1. Subject with premature ovarian failure
2. Subject with endocrine abnormalities such as hyperprolactinaemia or thyroid dysfunction
3. Subject with malformation or absence of uterus
4. Subject has tested positive for Human Immunodeficiency Virus (HIV) or Hepatitis B (by local laboratory; results obtained within 1 year prior to signing ICF are considered valid).
5. Subject with contraindication or allergy/hypersensitivity to hCG, estrogen and progesterone

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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2 participants in 1 patient group

In vitro Maturation

Experimental group

Description:

in vitro maturation of immature oocytes

Treatment:

Procedure: Polar Body Biopsy with preimplantation genetic screening

Procedure: in vitro maturation