In Vivo Glycocalyx as Predictor of Complications After Cardiac Surgery (GLYPOCS)

University Hospital, Rouen

Status: Unknown

Conditions: Endothelial Dysfunction; Surgery; Cardiovascular Diseases

Study type: Observational

Funder types: Other

Identifiers

NCT04643535

2020/202/OB

Details and patient eligibility

About

Cardiac surgery has been described as altering endothelium structure and function, notably because of the use of cardiac-pulmonary bypass (CPB). Among the endothelial structure, glycocalyx, the thin layer recovering the endothelial surface, may be altered by the inflammatory process and probably the modification of flow during CPB. Endothelial and glycocalyx integrity are essential for vascular function and glycocalyx destruction is associated with organ failure and mortality. On the other hand, a chronic alteration of glycocalyx is observed in many diseases such as diabetes, hypertension or chronic kidney failure, all pathologies frequently observed in patients benefiting grom cardiac surgery.

Thus the preoperative alteration of glycocalyx may be associated with postoperative organ failure.

Enrollment: 600 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• all patients benefiting from a cardiac surgery with cardio-pulmonary bypass

Exclusion criteria

• impossibility to carry out the measurement by glycocheck device
• refusal to participate