In Vivo Optical Spectroscopy Monitoring in a New Model of Muscular Compartment Syndrome

Université Catholique de Louvain

Status and phase: Completed; Phase 1

Conditions: Human Volunteers

Treatments: Device: EMG assessment; Device: Tourniquet; Device: INVOS assessment

Study type: Interventional

Funder types: Other

Identifiers

NCT01452425

B40320107753

Details and patient eligibility

About

Muscular compartment syndrome (MCS) is consecutive to an increase in intramuscular compartment pressures, and is a rare but serious postoperative complication.

The INVOS (In Vivo Optical Spectroscopy) monitors tissular oxygenation continuously and non-invasively.

The objective is to develop a model mimicking the physiopathology of MCS to assess the interest of the INVOS in this case.

Full description

After inflation of a tourniquet (pressure equal to the mean arterial pressure, we will obtain a model of slight venous congestion and arterial hypoperfusion. A comparison will be made between INVOS monitoring, sensory deficits, pain, electromyography and invasive pressure.

Enrollment: 10 patients

Sex: Male

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers
• >18yr
• Informed consent
• Male

Exclusion criteria

• Neuropathies
• Vascular pathology
• Actual pain
• Anti-platelet or anticoagulant therapy
• Ipsilateral history of fracture

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

Tourniquet

Experimental group

Description:

Inflation of a tourniquet

Treatment:

Device: EMG assessment

Device: Tourniquet

Device: INVOS assessment