In Vivo Quantification of Short Chain Fatty Acids Production in the Human Colon

Catholic University (KU) of Leuven

Status

Completed

Conditions

Healthy

Treatments

Dietary Supplement: Arabinoxylan oligosaccharides

Dietary Supplement: Dietary fiber enriched bran

Study type

Interventional

Funder types

Other

Identifiers

s55383

Details and patient eligibility

About

During this project the amount of SCFA produced in the colon after consumption of 2 different 13C-labelled wheat fiber fractions will be quantified.

Enrollment

10 patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Exclusion criteria

Calorie restricted diet or other special diet during the study or during the last month prior to the study
Antibiotics in the month prior to the study
Former surgeries on the gastrointestinal tract, with the exception of an appendectomy
use of the following types of medications with effects on the gastrointestinal tract during the last 2 weeks prior to the study (spasmolytica, anti-diarrhea, anti-constipation, probiotics)
Chronic disease of the gastrointestinal tract such as Crohn's disease, ulcerative colitis, irritable bowel syndrome, chronic constipation, chronic frequent diarrhea, clinically relevant lactose intolerance
Pregnancy, pregnancy desire or breastfeeding
Diabetes (type 1 and 2)
Blood donation in the past 3 months prior to the study
Abnormal hemoglobin (Hb) levels in blood, men must have a Hb level between 14.0 and 18.0 g / dL and women between 12.0 and 16.0 g / dL
Participation in studies in the past year in which radiation was used.