In Vivo Study of Sucrose and Liquid Oral Pediatric Medicines of Long-term Effect on Dental Biofilm pH (SPMedicines)

Federal University of Paraíba

Status and phase: Completed; Phase 2

Conditions: Dental Biofilm pH

Treatments: Other: G1, G2 and G3; Other: G4 and G5

Study type: Interventional

Funder types: Other

Identifiers

NCT01819350

SOPM-UFPB

Details and patient eligibility

About

The aims of this study were to determine the sucrose and liquid oral pediatric medicines of long-term effect on dental biofilm pH to evaluate the cariogenic potential in vivo.

Full description

Te study was carried out with 12 subjects that were refrained from brushing their teeth for 28 h and did not eat or drink for at least 3 h prior to each appointment. Dental biofilm pH was measured in the cervical and proximal regions of anterior teeth with beetrode-type microelectrode coupled to a potentiometer. The biofilm was submitted nine paediatric medicines a long term and sucrose (negative control). pH measurements were taken at baseline to determine resting plaque pH and at time interval 5, 10, 15, 20, 25 and 30 minutes.

Enrollment: 12 patients

Sex: All

Ages: 18 to 22 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18 to 22 years;
• Having Oral hygiene adequate (OHI<1.1);
• Having 20 natural teeth incluing molar;
• Not havind oral disease.

Exclusion criteria

• Biofilm baseline pH > 5,5;
• Not signature consent term;
• Using orthodontic appliance;
• Having used medicines last 3 months;
• Pregant woman.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Triple Blind

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12 participants in 2 patient groups

G4 and G5

Experimental group

Description:

Application of antibiotic group of pediatric medicines and control group (sucrose 10 %)on dental biofilm.

Treatment:

Other: G4 and G5

G1, G2 and G3

Experimental group

Description:

Application of Nutritional, Respiratory and Endocrine groups medicines pediatric on dental biofilm

Treatment:

Other: G1, G2 and G3