Inappropriate Prescribing of Proton-pump Inhibitor is it Associated With the Burden of Comorbidities in Older Patients? (IPP SA)

Nantes University Hospital (NUH)

Status: Completed

Conditions: Geriatric Disorder

Study type: Observational

Funder types: Other

Identifiers

NCT02841852

RC13_0262

Details and patient eligibility

About

Proton pump inhibitors (PPIs) are one of the most frequently prescribed classes of drugs in the world and the most effective drugs available to reduce gastric acid secretion. However, studies have shown that PPIs are not always prescribed with a clear indication. Indeed, between 25% and 86% of older individuals taking a PPI have been overprescribed these medications. In older patients, overprescribing of a PPI is associated with increases in morbidity, adverse drug events, hospitalization, and mortality. The hypothesis is that overprescription of PPIs is associated with the individual multimorbidities in older patients evaluated using the multimorbidities group criteria included in the CIRS. The aim of the present study was to establish a relationship between overprescribing of PPIs and multimorbidities in older patients.

Enrollment: 280 patients

Sex: All

Ages: 75+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients of 75 years or more
• Patients hospitalized in geriatric short stay
• Patients with an inhibitor therapy proton pump short geriatric entry
• Patients who have given their written consent

Exclusion criteria

• Patients who have expressed their inability or refusal to sign an informed consent