INCB047986 in Rheumatoid Arthritis

Incyte

Status and phase: Terminated; Phase 2

Conditions: Rheumatoid Arthritis

Treatments: Drug: INCB047986; Drug: Placebo

Study type: Interventional

Funder types: Industry

Identifiers

NCT02151474

INCB 47986-202

Details and patient eligibility

About

The purpose of this study is to explore the safety, tolerability and efficacy of INCB047986, in subjects with moderate to severe rheumatoid arthritis.

Full description

This will be a double-blind, placebo-controlled study with 4 parallel treatment groups. Subjects will be screened for up to 28 days before study drug administration to ensure that all eligibility criteria are met. On Day 1, subjects will be randomized to 1 of 4 dose groups of 15 subjects each (INCB047986 4 mg, 8 mg, 12 mg, or placebo QD). Study drug will be self administered on Days 1 through 28. A follow-up telephone call to the subject to assess safety will occur at Day 42. A final safety and efficacy evaluation will be performed at the Day 58 visit.

Enrollment: 3 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Men or women aged 18 to 75 years, inclusive.

• Body mass index between 18 and 40 kg/m^2, inclusive.

• Subjects must have a diagnosis of rheumatoid arthritis (RA) of at least 6 months' duration at the time of screening and must satisfy the ACR/European League Against Rheumatism (EULAR) 2010 Classification Criteria (Appendix B).

• Subjects must have active moderate to severe RA as determined by the following:

  • ≥ 6 tender joints (28 joint count),
  • ≥ 4 swollen joints (28 joint count), and
  • CRP level ≥ 6 mg/L.

• Subjects must have a negative tuberculosis (TB) test (QuantiFERON®-TB Gold test or purified protein derivative (PPD)) at screening.

Exclusion criteria

• Current or recent history of severe and/or progressive uncontrolled renal, hepatic, hematologic, gastrointestinal, pulmonary, cardiac, neurological, or cerebral disease.
• Current or recent history (< 30 days before screening and/or < 45 days before randomization) of a clinically meaningful bacterial, fungal, parasitic, or mycobacterial infection.
• Onset of RA before the age of 16 years.
• History of known or currently suspected inflammatory disease other than RA
• Current regimen of prednisone or equivalent with an average daily dose of > 10 mg or having been treated with a stable daily dose ≤ 10 mg for < 6 weeks.
• Previous treatment with at Janus kinase (JAK) inhibitor.
• Significant impairment of bone marrow function present at screening
• Receipt of any live vaccine within 2 months before screening or anticipated need for a live vaccine within the 2 months after last dose of study drug.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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3 participants in 4 patient groups

INCB047986 4 mg QD

Experimental group

Description:

INCB047986 4 mg will be orally self-administered once daily (QD) for 28 days.

Treatment:

Drug: INCB047986

INCB047986 8 mg QD

Experimental group

Description:

INCB047986 8 mg will be orally self-administered once daily (QD) for 28 days.

Treatment:

Drug: INCB047986

INCB047986 12 mg QD

Experimental group

Description:

INCB047986 12 mg will be orally self-administered once daily (QD) for 28 days.

Treatment:

Drug: INCB047986

INCB047986 placebo QD

Experimental group

Description:

INCB047986 placebo will be orally self-administered once daily (QD) for 28 days.

Treatment:

Drug: Placebo