Incidence and Nature of Heparin-induced Skin Lesions in Medical Patients

Johann Wolfgang Goethe University Hospital

Status: Unknown

Conditions: Allergy

Study type: Observational

Funder types: Other

Identifiers

NCT00510432

16/07

Details and patient eligibility

About

An increased number of patients with heparin-induced skin lesions is reported in the literature. Heparin-induced skin lesions may result from either occlusion of cutaneous vessels in patients suffering from autoimmune HIT or from a type IV allergic reaction (delayed type hypersensitivity (DTH) response). However, the incidence and nature of heparin-induced skin lesions has not been determined in a prospective investigation.

To address this open issue is the goal of this ongoing, so far monocenter, clinical investigation.

Enrollment: 500 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age > 18 Y.
• s.c. anticoagulant therapy >6 days

Exclusion criteria

• history of HIT
• history of DTH to heparin

Trial design

500 participants in 1 patient group

s.c. anticoagulant therapy

Description:

All patients with s.c. anticoagulant therapy (UFH, LMWH, heparinoids, fondaparinux)