Incidence and Risk Factor of Post-ERCP Pancreatitis in Chronic Pancreatitis

Naval Military Medical University

Status: Completed

Conditions: Post-ERCP Acute Pancreatitis

Treatments: Other: chronic pancreatitis

Study type: Observational

Funder types: Other

Identifiers

NCT02781987

13QA1404600 (Other Grant/Funding Number)

81470884 (Other Grant/Funding Number)

81422010 (Other Grant/Funding Number)

PEP-CP

81270541 (Other Grant/Funding Number)

Details and patient eligibility

About

The purpose of this study is to compare the incidence of post-ERCP pancreatitis (PEP) in chronic pancreatitis (CP) patients to that in biliary disease patients, to determine whether CP patients in early clinical stage have a higher PEP incidence, and to identify the predictive and protective factors for PEP in chronic pancreatitis patients.

Full description

Analysis of patients with chronic pancreatitis (CP group) and biliary disease (BD group) in Changhai Hospital from January 2011 to May 2015 were conducted. Difference of PEP incidences between BD group and CP group, as well as between M-ANNHEIM subcategories were calculated by chi-square test or Fisher's exact test. The predictive and protective factors for PEP were investigated by univariate and multivariate analysis.

Enrollment: 2,028 patients

Sex: All

Ages: 5 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with an endoscope inserted to cannulate the pancreatic/biliary duct were included.

Exclusion criteria

• patients in whom the papilla of Vater was not reached;
• patients who underwent stent removal procedures without ductal cannulation;
• patients in whom the intubation was failed.

Trial design

2,028 participants in 2 patient groups

CP group

Description:

Those patients with chronic pancreatitis underwent ERCP for pancreatic stone clearance, pancreatic stent placement, etc..

Treatment:

Other: chronic pancreatitis

BD group

Description:

Those patients with biliary ductal disease, such as choledocholithiasis, underwent ERCP to relieve outflow obstruction of the common bile duct.