Incidence and Risk Factors for Post-Anesthetic Morphine Titration in Recovery Room After Hip and Knee Arthroplasties (PAMTA)

Hôpital Privé Sévigné

Status: Active, not recruiting

Conditions: Arthropathy of Hip; Arthropathy of Knee

Treatments: Drug: IV morphine administered during the PACU stay

Study type: Observational

Funder types: Other

Identifiers

NCT06832995

2024-HPS

Details and patient eligibility

About

Despite the use of multimodal analgesia combining nerve block (NB) and systemic analgesia, intravenous (IV) morphine titration in the post-anesthetic care unit (PACU) after total hip (THA) and knee (TKA) arthroplasty is required to relieve early moderate-to-severe pain. Sedation occurrence during titration and a VAS score higher than 60/100mm are two independent risk factors for postoperative pain during hospitalization.

The association of NB and multimodal analgesia constitutes the reference in evidence-based recommendations. An adductor or femoral triangle block, alone or associated with periarticular infiltration, is recommended during TKA. During THA, NB associated with surgical periarticular infiltration improves analgesia and rehabilitation This study aims to identify the incidence and risk factors of morphine titration in PACU after lower limb arthroplasty performed by 5 experienced surgeons and using a multimodal analgesic procedure

Enrollment: 300 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Total hip arthroplasty
• Total Knee Arthroplasty
• Uni-compartmental knee arthroplasty (UKA)

Exclusion criteria

• Bilateral surgery Surgical revision Hip fracture surgery Other osteoarticular procedure(s) associated to hip/knee arthroplasty Refusal to use data Contra-indication of paracetamol, ketoprofen and dexamethasone

Trial design

300 participants in 2 patient groups

group T: IV morphine administered during the PACU stay

Treatment:

Drug: IV morphine administered during the PACU stay

group NT: no titration required in PACU