Incidence and Severity of Silent and Apparent Cerebral Embolism After Conventional and Minimal-invasive Transfemoral Aortic Valve Replacement

University Hospital Bonn (UKB)

Status: Completed

Conditions: Aortic Valve Disease; Cerebral Stroke

Study type: Observational

Funder types: Other

Identifiers

NCT00883285

255/08

Details and patient eligibility

About

The purpose of this study is to compare the incidence of silent and apparent cerebral embolism between conventional and minimal-invasive transfemoral aortic valve repair.

Full description

Patients undergoing aortic valve repair (AVR) are included prospectively into the study. AVR techniques include the conventional technique, the transfemoral and the transapical approach. Before the intervention CT of the chest is performed preoperatively to assess the degree of aortic and aortic valve calcification. Patients undergo MRI of the brain, including diffusion weighted imaging (DWI) and neurological assessment (NIHSS score) within 48 h before and after the procedure to assess occurrence of cerebral embolism.

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• aortic valve replacement

Exclusion criteria

• contraindication to undergo MRI

Trial design

60 participants in 3 patient groups

1

Description:

conventional aortic valve replacement

2

Description:

transfemoral aortic valve replacement

3

Description:

transapical aortic valve replacement