Incidence, Diagnosis, Management and Outcome of Acute Mesenteric Ischemia (AMESI)

University of Tartu

Status: Completed

Conditions: Acute Mesenteric Ischemia

Treatments: Other: No intervention

Study type: Observational

Funder types: Other

Identifiers

NCT05218863

AMESI Study

Details and patient eligibility

About

This is a prospective, multicentre observational study screening all adult patients admitted to a participating hospital over a 6-month study period (may be adjusted to 4-8 months according to recruitment) and including all patients with suspicion of or confirmed acute mesenteric ischaemia (AMI).

Only admission data and hospital mortality outcome will be collected for patients in whom suspicion of AMI is not confirmed. For patients with confirmed AMI full data collection regarding diagnostics, management and long-term outcome is required.

Investigators aim to recruit 40-50 sites with expected median of 10-20 patients with confirmed AMI per site during the study period (naturally depending on the size of the hospital). The start of the study is planned for Spring 2022.

The aim of the study is to identify the incidence of AMI and its different forms in adult hospitalized patients, and to describe patient characteristics (demographic, clinical and laboratory) at baseline, applied diagnostics and management, as well as outcomes in patients with AMI. An additional aim is to compare the baseline characteristics and outcomes of patients with confirmed AMI to those of patients with suspected AMI in whom the diagnosis was not confirmed.

Enrollment: 709 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

All patients with suspected AMI

Exclusion criteria

Age <18 years Consent declined by patient or next of kin Chronic mesenteric ischaemia without an acute event

Trial design

709 participants in 2 patient groups

Confirmed AMI

Description:

Patients in whom diagnosis of acute mesenteric ischaemia (AMI) was confirmed. For these patients full data collection is required, including 1-year outcome. Maximum 500 patients in this group.

Treatment:

Other: No intervention

AMI suspected but not confirmed

Description:

Patients in whom acute mesenteric ischaemia (AMI) was suspected but not confirmed. For these patients minimal data will be collected, only hospital survival as outcome. Maximum 2000 patients in this group.

Treatment:

Other: No intervention