Incidence of Delirium in Hip Fracture Patients Randomized to Regular Hypnotics vs Placebo

Hvidovre University Hospital

Status and phase: Terminated; Phase 4

Conditions: Delirium; Hip Fracture

Treatments: Drug: Zolpidem

Study type: Interventional

Funder types: Other

Identifiers

NCT00286936

HHSG-RCT-05

Details and patient eligibility

About

To examine the influence of regular hypnotic therapy on the incidence of delirium after hip fracture surgery

Full description

Delirium is prevalent after hip fracture surgery. Delirium has been linked to postoperative sleep disturbances. Zolpidem is a non-benzodiazepine hypnotic that preserves REM sleep. The present study investigates the incidence of delirium in hip fracture patients randomized to Zolpidem treatment 5 mg vs placebo in the perioperative phase.

Enrollment: 96 estimated patients

Sex: All

Ages: 70+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Primary hip fracture, no substance abuse, no regular opioid, corticosteroid or benzodiazepine therapy, hepatic insufficiency, myastenia gravis, allergies to drug components

Exclusion criteria

• Severe respiratory insufficiency

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind